SurgihoneyRO

SurgihoneyRO™ is an antimicrobial wound gel that incorporates Matoke’s cutting-edge Reactive Oxygen technology in a bioengineered honey.

SurgihoneyRO™ provides enhanced healing and a powerful antimicrobial action to reduce the microbial load thus removing the barriers to wound healing. It is the only antimicrobial wound dressing to be successfully tested against the WHO priority pathogens. [6]

1

Kills a wide range of bacteria in vitro [1,2,3]

2

Prevents biofilm in vitro [1]​

3

Fast acting antimicrobial action [2]

4

Substantially eradicates mature biofilm in vitro [4,5]​

5

Effective against multi drug-resistant microorganisms commonly found 
in chronic wounds [6]

6

Effective debridement​

For more information about SurgihoneyRO™ and information on how to buy, please contact us.

Case studies (In vitro)

SurgihoneyRO™ is an antimicrobial wound gel that incorporates Matoke’s cutting-edge Reactive Oxygen technology in a bioengineered honey.

A 77 year old patient with peripheral vascular disease presented with an infected sloughy discharging leg ulcer which was not healing. Samples were collected for microbiology and the ulcer washed with saline to remove slough. The microbiology sample showed a mixed growth of organsims which included MRSA, resistant coliforms and Pseudomonas aeruginosa. The vascular surgery team were keen to start broad spectrum intravenous antibiotics with meropenem (a last resort agent). As the patient did not have sepsis or spreading infection, antibiotics were withheld and topical treatment with Reactive Oxygen® was commenced. By day 10 the ulcer was clean and showed health healing granulation tissue.

Dryden M, Milward G, Saeed K. Infection prevention in wounds with Surgihoney. J Hosp Infect. 2014 Oct;88(2):121-2. doi: 10.1016/j.jhin.2014.07.008. Epub 2014 Aug 1. 1.

Swabs showed complete eradication of the multiply resistant Gram-negatives which would have presented a major infection control risk to the hospital. The wound was successfully resolved and avoided limb amputation.

Dryden M, Milward G, Saeed K. Infection prevention in wounds with Surgihoney. J Hosp Infect. 2014 Oct;88(2):121-2. doi: 10.1016/j.jhin.2014.07.008. Epub 2014 Aug 1.

An 18-year-old girl run over by a tractor suffered multiple fractures of the tibia. Image 1 shows that the soft tissue has become heavily colonised and infected with resistant coliforms and there is a risk of infection proceeding down the pins which could result in infection of the bone and loss of the limb. After daily treatment of the soft tissue with Reactive Oxygen®, image 2 shows a reduction in inflammation, control of microbial growth and prevention of deep seating infection.

Publications

Halstead F, Webber M, Rauf M, Burt R, Dryden M, Oppenheim B. In vitro activity of an engineered honey, standard medical-grade honeys and antimicrobial wound dressings against biofilm-producing clinical bacterial isolates. Journal of Wound Care, Feb 2016.

Dryden M. Lockyer G. Kordo S. Cooke J. Engineered honey: in vitro antimicrobial activity of a novel topical wound care treatment. Journal of Global Antimicrobial Resistance 2014. 10.1016/j.jgar.2014.03.006.

Dryden M, Milward G, Saeed K. Infection prevention in wounds with SurgihoneyRO™. Journal of Hospital Infection 2014.Oct;88(2): 121-2.doi:10.1016/j. jhin.2914.07.008.Epub 2014 Aug1.

Perfectus Biomed report May 2017, data on file.

Halstead F, Use of an engineered honey to eradicate pre-formed biofilms of important wound pathogens: an in vitro study, Journal of Wound Care, 2017.

Perfectus Biomed report 2018, data on file.